[Deff]

<pre>
f = str.match(re)
 re = ???

 str = "+=43534"
 f = null

 str = "++2323"
 f = "null"

 str = "=343434"
 f = null

 str = "dsfsdf"
 f = "dsfsdf"

 str = "=43gfvb"
 f = "gfvb"

 str = "+====+"
 f = "===+"
</pre>

<script type="text/javascript">
function TstFunc()  {
 var a = document.getElementById('Input');
 var str = a.value;
 var str2= str.replace(/\+?[\+=]\d*/i,'')

 alert(str2)
}
</script>
<input id="Input" type="text"  value="+=43534"><input type="button" value="Test" onclick="TstFunc()">