[рони]

pvjq,

<table>
	<tbody>
		<tr>
			<td><span id="1">Тут кусок тек...<span id="2">Тут кусок текста</span></span></td>

		</tr>
	</tbody>
</table>
 <script>
   var one = document.querySelector("[id='1']"),two = document.querySelector("[id='2']");
   one.firstChild.data = "12345";
   two.firstChild.data = "67890";

 </script>