dima-kruglyak,
<!DOCTYPE html>
<html>
<head>
<title>Untitled</title>
<meta charset="utf-8">
<style type="text/css">
</style>
<script src="https://ajax.googleapis.com/ajax/libs/jquery/1.12.4/jquery.min.js"></script>
<script>
$(function() {
$(".block-1").each(function (indx, el) {
$(el).on('input', 'input', function(event) {
var total = (parseInt($( ".block-col", el).val()) * parseInt($( ".block-price",el ).val()))||"";
$('.block-total', el).text(total);
});
});
});
</script>
</head>
<body>
<div class="block-1">
<div class="block-1-1">
<input type="text" value="1" class="block-col">
<input type="text" value="5" class="block-price">
<span class="block-total"></span>
</div>
</div>
<div class="block-1">
<div class="block-1-1">
<input type="text" value="1" class="block-col">
<input type="text" value="5" class="block-price">
<span class="block-total"></span>
</div>
</div>
</body>
</html>