[ksa]

Johny, как вариант

<script>
function Go() {
   var re=/\d\d\d/
   var o=document.getElementsByTagName('div')
   var i
   for (i=o.length; i>0; i--) {
      if (o[i-1].className.search(re) !=-1) {
         o[i-1].parentNode.removeChild(o[i-1])
      }
   }
}
</script>
 
<div class='div-123'>div-123</div>
<div class='test'>test1</div>
<div class='div-321'>div-321</div>
<div class='test'>test2</div>
<div class='div-123'>div-123</div>

<input type='button' value='Go' onclick='Go()' />