Можно, например, так
<html>
<head>
<meta charset="utf-8">
</head>
<body>
<div id="box">
<span><input type="checkbox">Internet Explorer</span></br>
<span><input type="checkbox">Opera</span></br>
<span><input type="checkbox">Firefox</span></br>
</div>
<script type="text/javascript">
(function() {
document.getElementById("box").onclick = function(e) {
var x = e ? e.target : event.srcElement;
x.parentNode.removeChild(x);
}
})();
</script>
</body>
</html>